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But discoveries in neuroplasticity have rewritten that story

These findings suggest isoform-selective HDAC inhibitors could provide more precise and safer therapeutic strategies compared with broad-spectrum HDAC blockade

doi: 10.3389/fpsyt.2025.1700059 Received 05 September 2025 Revised 19 November 2025 Accepted 26 November 2025 Published 11 December 2025 Volume 16 - 2025 Edited by Atsuo Fukuda, Hamamatsu University School of Medicine, Japan Reviewed by Hao Zhou, Guizhou Provincial Peoples Hospital, China Yulu Song, Johns Hopkins University, United States Updates Copyright 2025 Minami, Matsuoka, Takahashi, Ueda, Ohnishi, Fujimoto, Yoshikawa, Ishida, Takado, Near, Yamatani, Miyasaka, Tai, Ochi, Tanaka, Okada, Iwata and Makinodan

( Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest